With smart DMPK strategies, cross-domain collaboration, and strong CDMO support, companies are pushing past the challenges of ...

For the first time, a team of experts from the Technical University of Munich (TUM), RWTH Aachen University, and the German ...

In hepatocytes, bile acids are secreted into bile canaliculi by bile salt export pump (BSEP), cholesterol is secreted by ATP binding cassette subfamily G member 5 (ABCG5) and ABCG8 heterodimer and ...

Inflammation and scarring of the bile ducts—also known as cholangiopathies—can stop the bile from flowing, a vital fluid that helps digest fats. When bile can’t move through these ducts, it backs up ...

Biliary atresia is a rare, life‐threatening congenital disorder marked by the obliteration or absence of bile ducts, which leads to cholestasis and rapid progression to cirrhosis if left untreated.

Bile acids, synthesised from cholesterol in the liver, are central to lipid digestion but also serve as signalling molecules that regulate metabolism, inflammation and cellular homeostasis. In ...

Have you had your gallbladder removed and still suffer from symptoms like loss of appetite, nausea, diarrhea, constipation or weight gain? The gallbladder works in tandem with the liver, storing bile ...

Jaundice is considered a liver-related condition, but when it appears alongside abdominal pain, the cause may lie in the bile ...

Pale stools signal potential problems with the liver, gallbladder, or pancreas. This change in colour suggests bile flow issues. Certain medicines and alcohol can also affect stool colour. Jaundice ...

Doctors can test for gallbladder issues using a combination of physical exams, blood tests, and imaging studies. Several issues can affect the gallbladder, including gallstones, inflammation, or ...