High-resolution imaging has revealed the internal layout of chromatin condensates, showing how DNA fibers fold and interact ...

New ultra-detailed imaging exposes the hidden structure and behavior of chromatin condensates — and hints at how their ...

Inside human cells, biology has pulled off the ultimate packing job, figuring out how to fit six feet of DNA into a nucleus ...

Understanding how regulatory T cells (Tregs) develop and work is key to determining how they might be manipulated to encourage the destruction of cancer cells or prevent autoimmunity. Cell behavior is ...

A team led by HHMI Investigator Michael Rosen used advanced imaging techniques to understand how fibers of compacted DNA and proteins are organized and interact inside membrane-less, droplet-like ...

The developmental period is a critical window during which environmental cues interact with the genome to shape lifelong trajectories of health and disease.

Researchers discovered that stiff DNA segments inside nucleosomes physically block chromatin remodeling. The remodeling machinery normally shifts DNA by creating 20–30 base-pair loops, but these ...

Researchers have developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide. The new ...

Immune cells in the blood may be intimately involved with Alzheimer’s pathogenesis in the brain. At least, according to their chromatin. A study published January 31 in Neuron reported that in people ...

Inside every human cell, six feet of DNA folds into a nucleus that is only a few micrometers wide, yet still manages to ...