DNA polymerase requires two processing factors, sliding clamps and clamp loaders, to direct rapid and accurate duplication of genomic DNA. In eukaryotes, proliferating cell nuclear antigen (PCNA), the ...

An elusive step in the process of human DNA replication has been observed, for the first time, by scientists. The step, which is crucial for DNA replication in humans and other forms of life, had ...

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies. The findings visualize for the ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 38 (September 22, 2020), pp. 23571-23580 (10 pages) DNA replication requires the sliding clamp, a ...

An elusive step in the process of human DNA replication has been observed for the first time, report scientists at Penn State University. The scientists say they’ve discovered how a key step in human ...

According to senior author Stephen J. Benkovic, an Evan Pugh Professor of Chemistry and Holder of the Eberly Family Chair in Chemistry at Penn State, the scientists "discovered how a key step in human ...

DNA replication is required to maintain the integrity of genomic information. This article describes the process of DNA replication, in a step-by-step manner. DNA replication requires unwinding of the ...

For the first time, an elusive step in the process of human DNA replication has been demystified by scientists at Penn State University. According to senior author Stephen J. Benkovic, an Evan Pugh ...