Drug discovery is shifting from static snapshots to moving pictures. Instead of inferring how medicines work from end results ...

A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled ...

Naloxone and Naltrexone sound alike, look alike chemically, and are both used to counter the misuse of opioids. But pharmacologically, they're strikingly different. This is why the two drugs are used ...

Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Researchers have taken a ...

Many people are familiar with histamine, a biological molecule that serves as a key driver of allergic reactions and other ...

Activation of the serotonin receptor, 5-HT1A, has been shown to regulate mood and cognition. The receptor is the primary target of buspirone, vilazodone, and gepirone, FDA-approved medications for the ...

High-resolution 3D image showing how the 5-HT1A receptor connects with internal signaling proteins (G proteins). The highlighted areas reveal key contact points between the receptor and two different ...

Glucagon-like peptide-1 (GLP-1) was first discovered in the 1980s as a regulator of glucose levels. Further research led to the creation of a stabilized GLP-1RA called semaglutide, the active ...