The matrix fibronectin protein is a multifunctional adhesive molecule that promotes migration and invasiveness of many tumors including melanomas. Increased fibronectin synthesis has been associated ...
ILT3-fibronectin interactions within the tumor microenvironment may form a stromal checkpoint that actively suppresses myeloid cell function and inhibits antitumor immunity NGM831 is designed to block ...
Plasma fibronectin has been proposed to play a role in wound healing. Studies with conditional knockout mice, however, indicate that fibronectin has more to do with protecting cells from ischemic ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 26 (Jun. 28, 2005), pp. 9200-9205 (6 pages) Fibronectin (FN) is a major matrix protein involved in ...
New research overseen by University of Colorado Cancer Center member Rebecca Schweppe, PhD, could lead to improved treatment for people with thyroid cancer characterized by a mutation in the BRAF gene ...
Inflammatory breast cancer (IBC) is the most lethal form of breast cancer . It spreads easily through the lymphatic and blood vessels, forming metastasis which can lead to multi-organ failure. New ...
A study led by researchers at Moffitt Cancer Center found that normal cells surrounding a tumor, known as cancer-associated ...
Researchers at University of California San Diego School of Medicine have discovered a molecular pathway critical to the initiation of pancreatic tumors. The mechanism could also contribute to the ...
NGM Biopharmaceuticals, a US-based biotechnology company, disclosed a fourth oncology development candidate on Aug. 23, 2021. The new candidate, NGM831, is an antagonist antibody designed to block the ...
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