EMBL scientists discovered self-sustaining inflammatory circuits in the bone marrow stem cell microenvironment that precede blood cancers. The illustration shows cancer cells against a background of ...

There is a challenge related to prostate and many other cancers that cancer cells form resistance to treatments as the disease progresses. However, these resistance mechanisms are not yet fully ...

The inflammatory tumor microenvironment (TME) is a complex network of cancer, immune, and stromal cells interacting through cytokines and growth factors to drive tumor growth, angiogenesis, and immune ...

Exosomes, which can be generated by various cells, exhibit a dichotomous role in inflammation, demonstrating both anti-inflammatory and pro-inflammatory effects. They possess the capacity to influence ...

Blood cancers such as leukemia are caused by genetic changes in the blood-forming stem cells of the bone marrow. Scientists at the University Medical Center Mainz have now shown how chronic ...

Researchers discovered that chronic inflammation fundamentally remodels the bone marrow, allowing mutated stem cell clones to quietly gain dominance with age. Reprogrammed stromal cells and interferon ...

Low-dose albumin-bound paclitaxel and enhancement of anti-PD-1 therapy in bladder cancer by shaping the inflammatory immune microenvironment through induction of mitochondrial stress: Results from the ...