-- The study presents the journey of designing and optimizing novel gut-restricted PHD inhibitors using the comprehensive generative chemistry engine Chemistry42. -- From initiation to preclinical ...

An international study led by Paolo Fiorina from Boston Children's Hospital and in collaboration with researchers from University of Milan highlights the beneficial effect of inhibiting the death ...

Nonsteroidal anti-inflammatory drugs increase the severity of human inflammatory bowel disease (IBD), but little is known about the mechanisms by which prostanoid inhibition modulates IBD. In April 1 ...

Yet, low dose use of NSAIDS is also related to gastrointestinal (GI) injury. Schemes to avoid GI complications, including those linked with NSAID use, are usually associated with unwanted side-effects ...

CAMBRIDGE, Mass., Dec. 11, 2024 /PRNewswire/ -- Inflammatory bowel disease (IBD), consisting primarily of ulcerative colitis and Crohn's disease, is a group of debilitating auto-immune disorders, ...