Researchers find that microglia function differently in males versus females, potentially having broad implications for how neurological diseases are studied. A collision happens. Someone is hurt, a ...

A collision happens. Someone is hurt, a head injury, a concussion. Just as the first responders arrive to help the person, inside the brain, another “crew” of responders is busy clearing debris and ...

The brain is a special organ, and immune cells there called microglia work to repair damage and maintain the health of neural networks. About ten percent of brain cells are estimated to be microglia, ...

The idea that infiltrating T cells contribute to a neurodegenerative environment in aging and in Alzheimer’s disease has gotten another boost. In the June 27 Nature Neuroscience, scientists led by ...

In Alzheimer’s disease, microglia pack on fat, which impairs phagocytosis. Now, scientists led by Christiane Ruedl of Nanyang Technological University, Singapore, report that blocking lipid buildup in ...

WEST LAFAYETTE, Ind. — It was long thought that fat in the brain played no role in neurodegenerative diseases, but Purdue University researchers are challenging that assumption. The research findings, ...

Microglia (green) responding to aggregated beta-amyloid plaques (blue) in the mouse cortex. In Alzheimer’s disease, the leading cause of dementia, microglia—the brain’s immune defenders—can act as ...

During development, there are known sex-related differences in how microglia function. But into adulthood, there was thought to be less variation in how they behave. Microglia maintain neuronal ...

Using Alzheimer’s mouse models, human cells, and human brain tissue, the researchers demonstrated that lowering PU.1 promotes the expression of lymphoid immunoregulatory receptor proteins on microglia ...

Microglia are a specialized type of immune cell that accounts for about 10% of all cells within the brain and spinal cord. They function by eliminating infectious microbes, dead cells, and aggregated ...

In the search for answers about Alzheimer’s disease, researchers are taking a close look at the immune system of the brain. A new study uncovers how a key immune cell, called a microglia, might be the ...

In Alzheimer's disease, the leading cause of dementia, microglia-the brain's immune defenders-can act as both protectors and aggressors, shaping how the disease progresses. Researchers from the Icahn ...