Mitotic stopwatch pathway shows how cancer loses its sense of time to avoid stress responses

When cell division (mitosis) takes too long, it can be a sign that something is wrong with the cells, for example, DNA damage ...
Nature

Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

Figure 1: Apcin binds to Cdc20 and inhibits APC/C-dependent ubiquitylation. Figure 2: Apcin binds to the D-box binding site of Cdc20. Figure 3: Effects of apcin on Cdc20 binding to APC/C and stability ...