Valosin-containing protein (VCP), also known as p97, is a critical AAA+ ATPase that maintains cellular protein homeostasis by orchestrating the unfolding, extraction, and processing of ubiquitinated ...

Scientists have uncovered a powerful ally in the fight against neurodegenerative diseases: a nucleolar complex that plays a pivotal role in maintaining cellular health through protein homeostasis ...

Scientists have uncovered a powerful ally in the fight against neurodegenerative diseases: a nucleolar complex that plays a pivotal role in maintaining cellular health through protein homeostasis ...

When improperly folded proteins build up in the endoplasmic reticulum (ER), cells become stressed and conditions such as type 2 diabetes, neurodegenerative disorders, and cancers can develop. In a ...

A research team led by Prof. XU Zhiheng from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has identified Tapt1, together with its partner Suco, as important ...

Immunologists from the Institute have been the first to uncover a role for a family of RNA binding proteins in the function of regulatory T cells in the immune system. As their name suggests, ...

A model of Fe homeostasis regulation by MdCML15–MdBT2–MdbHLH104–MdAHA8 in apple trees. When apple roots are exposed to Fe-sufficient conditions, MdCML15 is induced to interact with MdBT2 in the ...

Homeostatic plasticity of intrinsic excitability goes hand in hand with homeostatic plasticity of synaptic transmission. However, the mechanisms linking the two forms of homeostatic regulation have ...