Protein sequencing presents different challenges than nucleic acid sequencing, meaning that proteomics has yet to benefit as much as genomics from the next-generation sequencing revolution. However, ...

In ancient Greek lore, Proteus, son of Poseidon, held the allure of wisdom and foresight, yet could only be approached by those with the means to capture him. Much like this mythical figure, proteins, ...

Whether you’re interested in why a living system works as it does or the reasons it goes awry, proteins are a critical part of the molecular picture. The proteins circulating in a person’s plasma can ...

Misfolded proteins can appear as small aggregates, soluble monomers, or large insoluble inclusion bodies. While the fundamental biophysical mechanisms that cause cytotoxicity are not fully understood, ...

Proteins, through their diversity, are vital determinants of phenotype and function. Humans possess potentially millions of protein variants (proteoforms), derived through mechanisms including ...