Nature

Desmoplastic Small Round Cell Tumors

Desmoplastic small round cell tumors (DSRCTs) are a rare and aggressive form of soft tissue sarcoma that predominantly affects adolescents and young adults. Characterised by the pathognomonic ...
Nasdaq

Actuate Therapeutics, Inc. Reports Encouraging Results from Phase 1 Study of Elraglusib in Pediatric Ewing Sarcoma Patients and Plans Phase 2 Trial

Actuate Therapeutics, Inc. has announced the completion of the Phase 1 study evaluating its drug elraglusib in pediatric patients with refractory malignancies, specifically Ewing Sarcoma (EWS). The ...
The American Journal of Managed Care

First-Line Combo Yields Strong Results in Advanced Sarcoma

The phase 1/2 SAINT study is currently investigating intravenous trabectedin plus ipilimumab and nivolumab in the first line for advanced soft tissue sarcoma. The study investigators from City of Hope ...
ascopubs.org

ACR-368, a CHK1/2 Kinase Inhibitor, in Patients With Relapsed or Refractory Desmoplastic Small Round Cell Tumor: Phase I/II Trial Results

Real-World Utilization and Performance of Circulating Tumor DNA Monitoring to Predict Recurrence in Solid Tumors Preclinical data confirmed ACR-368 as potentially therapeutic in DSRCT, and 19 patients ...
Cure Today

T-Cell Therapy With Lete-Cel Demonstrates Efficacy in Sarcoma Subtypes

Letetresgene autoleucel (lete-cel) showed a 42% response rate in a phase 2 trial for synovial sarcoma and myxoid/round cell liposarcoma. The trial included 64 patients, with 41% response in synovial ...