This study offers important insight into the pathogenic basis of intragenic frameshift deletions in the carboxy-terminal domain of MECP2, which account for some Rett syndrome cases, yet similar ...

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive degradation of brain cells, as well as an associated decline in memory and other mental functions. Earlier ...

Heterozygous genotypes can affect traits like eye and skin color where one allele may be dominant over another. Certain diseases like sickle cell anemia and cystic fibrosis can have a heterozygote ...

HLA-B*58:01 and HLA-A*34:02 were linked to an increased risk for allopurinol-induced severe cutaneous adverse reactions, while no risks were found for HLA class II alleles. HealthDay News — Two human ...

TUESDAY, Nov. 4, 2025 (HealthDay News) -- Two human leukocyte antigen (HLA) class I alleles are independently associated with an increased risk for allopurinol-induced severe cutaneous adverse ...

The Polaris package consists of two distinct programs written in the C-Python language: (i) Panderas and (ii) Panderas_Plots that run in a command-line Terminal window on Mac OS X and Linux machines.

The majority of highly polymorphic genes are related to immune functions and with over 100 alleles within a population, genes of the major histocompatibility complex (MHC) are the most polymorphic ...

Genes and alleles are essential to basic genetics, but what are the differences between them? In this guide, we compare genes and alleles and provide simple definitions and examples for both. Genes ...

For 30 years, APOE4 has ranked as the strongest genetic risk factor for Alzheimer’s disease, with two copies boosting the odds up to 15-fold. Now, scientists argue that people with two APOE4 alleles ...

“Table for Two” is a collection of six stories and a novella set in two very different cultural capitals. By Hamilton Cain Hamilton Cain is a book critic and the author of “This Boy’s Faith: Notes ...

Researchers have uncovered a mechanism that safeguards the biallelic expression of haploinsufficient genes, shedding light on the importance of having two copies of each chromosome. A study by the lab ...