Frontiers

Export Control: Post-transcriptional Regulation of the COPII Trafficking Pathway

Department of Biochemistry, Duke University School of Medicine, Durham, NC, United States The coat protein complex II (COPII) mediates forward trafficking of protein and lipid cargoes from the ...
PNAS

TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER–Golgi intermediate compartments

The endoplasmic reticulum (ER) serves as a platform for the packaging of most secretory proteins into conserved coat protein complex II (COPII)-coated transport carriers destined for ER–Golgi ...
eLife

ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate

Native cargo proteins exit the endoplasmic reticulum (ER) in COPII-coated vesicles, whereas resident and misfolded proteins are substantially excluded from vesicles by a retention mechanism that ...
eLife

The structure of the COPII transport-vesicle coat assembled on membranes

Coat protein complex II (COPII) mediates formation of the membrane vesicles that export newly synthesised proteins from the endoplasmic reticulum. The inner COPII proteins bind to cargo and membrane, ...
Nature

COPII and the regulation of protein sorting in mammals

Sar1 GTP hydrolysis, necessary for vesicle fission 3,10, is stimulated by the GTPase-activating protein (GAP) Sec23, and is further accelerated by Sec31 (ref. 16). GTP hydrolysis also promotes coat ...
PNAS

Surface structure of the COPII-coated vesicle

The spatial arrangement of COPII coat protein subunits was analyzed by crosslinking to an artificial membrane surface and by electron microscopy of coat proteins and coated vesicle surfaces. The ...