Abstract: The focal mechanism provides seismological constraints on the geological faults that generate the earthquakes and thus is important for regional seismotectonic research. Focal mechanism ...

Contrary to findings from observational studies which are inherently affected by bias, digoxin use in randomised controlled trials (RCTs) did not lead to excess mortality in our meta-analysis of 87 ...

The Plausible Mechanism Pathway allows FDA drug approval without randomized trials, focusing on diseases with known biological causes. This pathway targets rare genetic diseases, emphasizing biologic ...

The plausible mechanism pathway “could accelerate gene therapy/editing development,” analysts at William Blair said Thursday, while adding that additional clarity is needed. Individualized therapies ...

MADRID -- Digitoxin added to guideline-directed medical therapy improved outcomes among patients with heart failure and reduced ejection fraction (HFrEF), the DIGIT-HF trial showed. The cardiac ...

Heart failure (HF) is the leading cause of hospitalization among older adults. Digoxin has been shown to reduce hospitalization due to worsening HF. However, at the commonly prescribed dose of 0.25 mg ...

Cardiac glycosides derived from the foxglove plant have been used in cardiology for two centuries, but digoxin and digitoxin have gradually fallen out of favor and are now considered controversial in ...

Intuitively, you think that everything that you stretch will pull back, but you wouldn’t expect a couple of pieces of plastic to win. Yet, researchers over at [AMOLF] have figured out a way to make a ...

Divers found the Antikythera mechanism in a shipwreck in 1900. Zde via Wikimedia Commons under CC BY-SA 4.0 More than a century ago, a group of sponge divers discovered a shipwreck near the Greek ...

The heart drug digoxin could potentially be combined with existing cancer therapies to prevent the spread of tumors, an early trial suggests. But questions remain. When you purchase through links on ...

Switching from beta-blockers to digoxin as first line therapy for heart rate control in older patients with atrial fibrillation (AF) and symptoms of heart failure could produce a cost saving of over ...