What if you could flip a genetic switch to silence a gene, then turn it back on with a simple drug? For researchers, gene-switch tools offer that kind of control—and a new system called Cyclone may ...

i have an issue with a very crowded sashimi plot of a whole gene that is difficult to read: this gets even worse if a add a white background to text. i know i could just zoom into the event, but i ...

Hello, I'm wondering if there's a setting or if other people have this issue as well (searching I could not find it). When we map with STAR, most of our data looks great. However, a small number of ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

Aided by two molecular control factors, the spliceosome rejects pre-mRNA that could be incorrectly spliced. While GPATCH1 detects the defective pre-mRNA, DHX35 removes it from the spliceosome, which ...

Construction of an O-GlcNAc responsive GFP biosensor. a. Schematic of the GFP reporter (left, drawn to scale) and predicted changes in reporter splicing and expression upon varying cellular O-GlcNAc ...

The ROCO family is a family of GTPases characterized by a central ROC-COR tandem domain. Interest in the structure and function of ROCO proteins has increased with the identification of their ...

cDepartment of Medical Genetics, Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia ...

iNtRON Grants Basilea exclusive right for preclinical evaluation with an undisclosed payment Basilea has the option to enter into exclusive License Agreement following the evaluation BOSTON and SEOUL, ...

Robert Cedergren Center for Bioinformatics and Genomics, Département de Biochimie, Université de Montréal, Montréal, QC, Canada Compared to nuclear genomes, mitochondrial genomes (mitogenomes) are ...