The Notch signaling pathway is a critical component of cardiovascular formation and morphogenesis in both development and disease. It is required for the selection of endothelial …

Mar 10, 2025 · This Review discusses how different modes of Notch signalling can have different functional outcomes, and how their dysregulation is associated with cancer states.

Dec 23, 2025 · Notch signaling is an evolutionarily conserved pathway in multicellular organisms that regulates cell-fate determination during development and maintains adult tissue …

Notch signaling. Following ligand binding, signaling is initiated when endocytosis of ligand–receptor complexes induces unfolding of a juxtamembrane negative control region …

Apr 29, 2025 · The Notch signaling pathway is a crucial communication system influencing cell differentiation, proliferation, and apoptosis. Its significance extends from embryonic …

Aug 1, 2025 · The Notch signaling pathway is essential for cell fate decisions and maintaining epigenetic memory during nervous system development. It regulates neural stem cell …

Mar 24, 2022 · We summarized both classical and cutting-edge findings of NOTCH signaling in this review, illustrating the history, architecture, regulatory mechanism, physiology, and …

The Notch signaling pathway plays a critical role in regulating cell communication. This pathway is essential in multiple biological processes including cell fate decisions, differentiation, and the …

Feb 20, 2025 · As a highly conserved intercellular signaling pathway, “Notch” was observed in a variety of eukaryotic organisms. It transmits signals through interactions between neighboring …

Mar 15, 2024 · In this review, we objectively summarize the molecular features of the Notch signaling pathway constituents, their current expression profiles, and their functions in …